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111.
Antim K. Maurya Gaurav Aggarwal Sachin Vashisath Vikas Kumar Prof. Dr. Vijai K. Agnihotri 《化学与生物多样性》2023,20(8):e202300223
The aim of current work was to determine essential oils (EOs) composition from three Eucalyptus species, including E. citriodora, E. camaldulensis and E. globulus and assess their α-glucosidase inhibitory activity. The EOs were collected using the hydrodistillation technique and characterized by GC/MS, GC-FID and NMR. The isolated EOs from leaves parts of Eucalyptus species varied from 0.56 to 1.0 % on fresh weight basis. The content of the EOs was distinct according to the species. The most abundant metabolites were identified as citronellal (0–83.0 %), 1,8-cineole (0.2–44.8 %), spathulenol (0.4–16.1 %) α-pinene (0.4–15.9 %), p-cymene (3.7–11.9 %), citronellol (0–8.6 %), β-eudesmol (5.3–8.6 %) and β-pinene (0–7.1 %). The EOs obtained from targeted samples exhibited strong α-glucosidase inhibitory activity. These results are encouraging and underline that the EOs of Eucalyptus species may be a promising alternative source of natural antidiabetic. 相似文献
112.
Despite the advantages of mathematical bioprocess modeling, successful model implementation already starts with experimental planning and accordingly can fail at this early stage. For this study, two different modeling approaches (mechanistic and hybrid) based on a four-dimensional antibody-producing CHO fed-batch process are compared. Overall, 33 experiments are performed in the fractional factorial four-dimensional design space and separated into four different complex data partitions subsequently used for model comparison and evaluation. The mechanistic model demonstrates the advantage of prior knowledge (i.e., known equations) to get informative value relatively independently of the utilized data partition. The hybrid approach displayes a higher data dependency but simultaneously yielded a higher accuracy on all data partitions. Furthermore, our results demonstrate that independent of the chosen modeling framework, a smart selection of only four initial experiments can already yield a very good representation of a full design space independent of the chosen modeling structure. Academic and industry researchers are recommended to pay more attention to experimental planning to maximize the process understanding obtained from mathematical modeling. 相似文献
113.
Rewilding incomplete ecosystems by using ungulate megaherbivores represents a significant potential for sustainable management of habitats of declining species. Two xeric grasslands patches in the Podyjí National Park, Czech Republic, were rewilded by a feral horse breed, the Exmoor pony, in 2018. Before this in 2017, demography, mobility, and adult habitat use of five congeneric Melitaea butterflies co-occurring at the grasslands were investigated (Vodickova et al., J. Nature Conserv. 2019). In 2021, four seasons after the rewilding, we replicated the survey to assess the effects of the horse on the butterflies. Here, we compare the results of the two surveys and investigate changes in spatial patterns of adult distribution using Ripley’s K-functions.Total numbers of captures, and estimated population sizes, were consistently lower in 2021, with the largest drop for spring-flying M. cinxia. We cannot discern whether this was due to the cold 2021 spring, or due to reduction of grasses by the horse, possibly contributing to desiccation of M. cinxia host plants. Demographic parameters such as residency/longevity and capture probability changed only little. Mobility ranking among species remained identical, but within species, some mobility characteristics changed among years. Among early summer species, M. britomartis, second most abundant in 2017, switched to the first position with M. aurelia, and these two species displayed the most notable shift in adult habitat use between the two seasons. Short thorny shrubs avoided by the horse protect M. britomartis host plants; this threatened butterfly thus did not suffer from horse presence. M. athalia, a species of woodland edges, profited from decay of conifers caused by a series of dry years; and M. didyma, forming multiple generations, from increase of its host plant. Contrary to expectations, spatial distribution of most butterflies became more aggregated within rewilded pastures, probably due to regularities in home ranges use by the horses, which restructured the vegetation in a zonal, rather than patchy, way. A considerably larger areas should be rewilded by the herbivores to fully achieve the desired beneficial effects. 相似文献
114.
摘要 目的:探讨乳腺良恶肿瘤患者超声弹性成像定量参数与临床分期、病理分子分型的相关性。方法:选择2020年1月至2022年12月来我院诊治的乳腺肿块患者85例,均行超声弹性成像检查,分析85例乳腺肿块患者的病理检查结果,对比良恶性肿瘤患者的弹性成像参数,对弹性应变率、直径变化率、面积比及三者联合绘制ROC曲线,分析不同乳腺肿瘤患者临床分期的弹性成像参数,分析乳腺肿瘤患者病理分子分型的弹性成像参数。结果:85例乳腺肿块患者中,良性肿块35例,恶性肿块50例。恶性组的弹性应变率、肿块直径、直径变化率、肿块面积、面积比明显较良性组低(P<0.05)。面积比ROC曲线AUC为0.580,以1.73为临界值,乳腺恶性肿瘤的诊断灵敏度为73.5 %,特异度为38.5 %;直径变化率ROC曲线AUC为0.630,以0.28为临界值,诊断灵敏度为75.5 %,特异度为47.5 %;弹性应变率ROC曲线AUC为0.790,以15.2 cm2为临界值,诊断灵敏度为64.5 %,特异度为83.5 %,以三者联合绘制ROC曲线,AUC为0.920,诊断灵敏度为82.5 %,特异度为92.5 %。乳腺恶性肿瘤患者TNM分期Ⅰ、Ⅱ、Ⅲ、Ⅳ期者的弹性应变率、肿块直径、直径变化率、肿块面积、面积比对比有统计学意义(P<0.05);其中Ⅳ期者的弹性应变率、肿块直径、直径变化率、肿块面积、面积比明显较Ⅲ、Ⅱ、Ⅰ期者高,Ⅲ期者明显较Ⅱ、Ⅰ期者高,Ⅱ期者明显较Ⅰ期高。乳腺恶性肿瘤患者Luminal A型者、Liminal B型者、Her2过表达型者、基底样型者的弹性应变率、肿块直径、直径变化率、肿块面积、面积比对比有统计学意义(P<0.05);其中Liminal B型者的弹性应变率、肿块直径、直径变化率、肿块面积、面积比明显较Luminal A型者、Her2过表达型者、基底样型者高,Her2过表达型者明显较Luminal A型者、基底样型者高(P均<0.05),Luminal A型者与基底样型者对比无统计学意义(P>0.05)。结论:超声弹性成像可用于乳腺良恶肿瘤的诊断,超声弹性成像定量参数可用于恶性乳腺肿瘤临床分期、Liminal B型、Her2过表达型的判断。 相似文献
115.
《Animal : an international journal of animal bioscience》2023,17(3):100706
Tibetan goats, Taihang goats, Jining grey goats, and Meigu goats are the representative indigenous goats in China, found in Qinghai-Tibet Plateau, Western pastoral area, Northern and Southern agricultural regions. Very few studies have conducted a comprehensive analysis of the genomic diversity and selection of these breeds. We genotyped 96 unrelated individuals, using goat 53 K Illumina BeadChip array, of the following goat breeds: Tibetan (TG), Taihang (THG), Jining grey (JGG), and Meigu (MGG). A total of 45 951 single nucleotide polymorphisms were filtered to estimate the genetic diversity and selection signatures. All breeds had a high proportion (over 95%) of polymorphic loci. The observed and excepted heterozygosity ranged from 0.338 (MGG) to 0.402 (JGG) and 0.339 (MGG) to 0.395 (JGG), respectively. Clustering analysis displayed a genetically distinct lineage for each breed, and their Fst were greater than 0.25, indicating that they had a higher genetic differentiation between groups. Furthermore, effective population size reduced in all four populations, indicating a loss of genetic diversity. In addition, runs of homozygosity were mainly distributed in 5–10 Mb. Lastly, we identified signature genes, which were closely related to high-altitude adaptation (ADIRF) and prolificity (CNTROB, SMC3, and PTEN). This study provides a valuable resource for future studies on genome-wide perspectives on the diversity and selection signatures of Chinese indigenous goats. 相似文献
116.
ZENG WenbingZHANG Weicheng XU ShiyuanYANG ZhizhongLIU ChunZHU DepingWEN QibinSHEN QixiangWANG Xianbin 《中国科学:生命科学英文版》1996,39(1):87-98
The mechanism of 13C-methacetin breath test is set forth clearly with the analysis of pharmacokinetics mode, and the measuring method of 13C-methacetin breath test and its clinical applications in the diagnosis of liver diseases are reported in detail. On the basis of comprehensive analysis of the clinical test data, the advanced diagnostic parameter S is of important significance for the application and development of breath test. 相似文献
117.
The mechanism of 13C-methacetin breath test is set forth clearly with the analysis of pharmacokinetics mode, and the measuring method of 13C-methacetin breath test and its clinical applications in the diagnosis of liver diseases are reported in detail. On the basis of comprehensive analysis of the clinical test data, the advanced diagnostic parameter S is of important significance for the application and development of breath test. 相似文献
118.
广西龙虎山猕猴种群生态特征 总被引:5,自引:1,他引:4
1988~1995年,采用定点观察法和绝对计数与相对计数结合法对龙虎山猕猴种群生态作了调查研究。1990年核心区有猕猴14群,500只左右,猴群密度1.6群/km2,种群密度55.6只/km2.猴群大小平均33.8±23.1(n=6)只。一般每隔4~5年分群一次,猴群群体年均增长率14.8%,种群年均增长率为9.7%。猴群中成年猴性比为7.6±6.5(n=12),1~3岁组的性比为0.74±0.61(n=4),群内未成年猴比例为67.7±3.1%(n=12)。发情交配期最早11月12日,最晚次年1月20日,高峰期12月上旬,持续3个月.产仔期最早4月1日,最晚8月14日,高峰期5月上旬,持续时间4个半月.繁殖率45.5%~100%,平均75.4±13.2%(n=21)。新生猴死亡率较低,新生猴性比(雌:雄)平均0.74±0.34(n=5)。 相似文献
119.
升流厌氧污泥层反应器动力学模型 总被引:1,自引:0,他引:1
用碘离子作示踪剂,采用矩形脉冲示踪法测定升流厌氧污泥层(UASB)反应器的流动分布。建立了申级返混加沟流模型。模型简单,能够反映反应器流动分布,具有较强的拟合能力和良好的适用性。运用流动模型和Monod方程,建立了UASB反应器稳态模型,并对模型参数进行了估计。通过灵敏度分析,进水基质浓度S。,废水流量Q,最大比基质降解速率,μmax 对出水基质浓度有较大影响。在稳态模型的基础上又建立了UASB反应器动态模态,利用此模型,对出水基质浓度序列Se,和产气量序列Qg进行计算预测,平均偏差分别5.40%和7.46%,标准偏差分别为7.02%和9.66%。 相似文献
120.
异视界绒螨(Allothrombium ignotum)种群密度与生态环境的关系 总被引:2,自引:0,他引:2
研究表明,无视异绒螨种群密度与棉田连作年限之间呈正相关,与棉田海拔高度和水位之间呈负相关.露地棉田螨量明显高于地膜覆盖棉田.若螨在静水中的浮水时间可持续5.2h.成螨产卵的最适土壤含水量为12.5%.不同杀虫剂对幼螨杀伤力为溴氰菊酯喷雾>氧化乐果喷雾>三氯杀螨醇喷雾>氧化乐果缓释剂涂茎.因此,发展灌溉棉田、棉花适当连作、棉花生长期采取药剂涂茎治蚜对壮大无视异绒螨种群密度有重要作用. 相似文献